jasmonat, metil ester jasmonat, dan etilen . Malignih limfoma, uključujući Hodgkin-ovu bolest i non-Hodgkin-ove limfome. Less than 18 years and greater than 10 kg: 1 to 2 mg/m2 IV over one minute once a week.399658 Da. Obat ini mengandung Vincristine sulphate yang digunakan sebagai obat kemoterapi untuk mengobati kanker darah (Leukemia limfoblastik akut; Leukemia mieloid akut), tumor otak, Neuroblastoma (kanker neuroblast atau sel-sel saraf yang belum matang pada anak-anak), kanker paru-paru, kanker kelenjar getah bening (Limfoma Feb 13, 2023 · Vincristine hanya tersedia dan hanya diberikan secara intravena. Vincristine is a chemotherapy medication used to treat various types of cancer, including leukemia, lymphoma, neuroblastoma, and Wilms tumor. Príbalový leták (PIL) Vincristin Teva (VšZP_L0153) sol inj 1x1 ml/ 1 mg (mimoriadny dovoz). You will be given vincristine in the chemotherapy day unit or during a stay in hospital. If given other ways, this drug can be deadly. Általában testfelület-négyzetméterenként 1,0-1,4 mg (összesen legfeljebb 2 mg) adható egyszeri adagként, hetente egy alkalommal. Vincristine can be given in combination with other cancer drugs. Erwachsene (einschließlich älterer Patienten) Die übliche Dosis bei Erwachsenen ist 1,4 mg/m2 (Höchstdosis 2 mg/m2) einmal wöchentlich. Neuroblastoma. Vincristine is an FDA-approved chemotherapy agent that is used to treat some types of blood cancer as well as some noncancerous conditions. Osobina Vrednost Broj akceptora vodonika: 12 Pharmacy medicines information 020 7829 8608 (Monday to Friday from 9am to 5pm) Vincristine is a chemotherapy medicine that is used to treat certain types of cancer. Vincristinsulfat darf nicht als Injektion in den Muskel (intramuskuläre Injektion), unter die Haut (subkutane Injektion) oder in den Rückenmarkkanal (intrathekale Injektion) verabreicht werden. Fertilitet TUGAS KELOMPOK FITOKIMIA OBAT-OBAT MODERN YANG BERASAL DARI TANAMAN VINBLASTIN ATAU VINKRISTIN Disusun Oleh : Nama :1.), podmínkách úhrady apod. Dosis maksimal sebesar 18,5 mg/m2 setiap minggu. Obat vinkristin ini mengikat tubulin protein dan menghentikan pembelahan Produksi vinkristin dan vinblastin dapat . It should be stored at 4°C and protected from light. Vinkristin se uporablja intravensko pri različnih vrstah raka, zlasti pri ne-Hodgkinovem limfomu, Hodgkinovem limfomu in tudi pri akutni limfoblastni levkemiji, nefroblastomu. jaw pain. (Bkz. After treatment with vincristine has ended, or sometimes even during treatment, normal hair growth should return. Vincristine is hoarseness or loss of ability to speak loudly.958 Da. Vincristinsulfat darf nicht als Injektion in den Muskel (intramuskuläre Injektion), unter die Haut (subkutane Injektion) oder in den Rückenmarkkanal (intrathekale Injektion) verabreicht werden. Secara umum, berikut ini adalah dosis penggunaan vinblastin: Dewasa: 3,7–18 mg/m 2 LPT per hari, tiap 7–10 hari. Táto písomná informácia pre používateľov bola naposledy schválená vo februári 2009. Felnőtteknek. Vincristine sulfate is approved to treat adults and children with: Acute leukemia. A chemotherapy nurse will give it to you. Pengikatan protein: Ekstensif. Vinkristin-sulfat se koristi kao monoterapija ili u kombinaciji sa drugim onkološkim lekovima za lečenje: Leukemija, uključujući akutnu limfocitnu leukemiju, hroničnu limfocitnu leukemiju, akutnu mijeloidnu leukemiju i blastne krize hronične mijeloidne leukemije. Obat ini termasuk ke dalam jenis alkaloid vinca. Vincristine Sulfate dapat diinjeksikan bersamaan dengan infus saline 0,9% atau glucose 5% atau diinjeksikan secara langsung ke vena selama periode 1 menit. Ayu Wulansari. jaw pain. Vincristine is a naturally occurring vinca alkaloid. [5] It is given intravenously. The anticancer drug vincristine is associated with potentially dose-limiting side-effects, including neurotoxicity and myelosuppression. vincristine will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. You may report side effects to FDA at 1-800-FDA-1088. So, it stops the growth of the cancer. Jan 31, 2024 · Common side effects of vincristine may include: hair loss; decreased weight with loss of muscle tissue; nausea, vomiting, diarrhea, weight loss; or. - 9 of 9 defined stereocentres. Tell your child’s nurse if your child has any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going Vinkristin sülfat bir vesikan olup, bölgesel reaksiyonlara veya ekstravazasyona sebep olabilir. Vincristine may increase the risk that you will develop other cancers. rash. Vincristine sulfate is a white to off-white powder.

Secara umum, dosis vincristine untuk orang dewasa adalah 1,4 mg/m 2, diberikan dalam interval satu minggu sekali. Bölüm 4. Treba voditi računa da se izbegne ekstravazacija jer to može dovesti do Injekcija razrijeđenog vinkristinsulfata može se infundirati putem fleksibilnog plastičnog spremnika (npr. Obat vinblastin diberikan melalui infus selama 5 – 10 menit atau Vinkristin je organsko jedinjenje, koje sadrži 46 atoma ugljenika i ima molekulsku masu od 824,958 Da. Osobine Osobina Vinkristiini on vinka-alkaloideihin kuuluva sytostaattisena syöpälääkkeenä käytettävä aine. dr. A növényben a vinkrisztin mellett vinblasztin és vincamin található. Tieto lieky zabraňujú rastu rakovinových buniek.. seizures.2). Vincristine is stable for 15 days at concentrations of 0. This drug inhibits cell growth by disrupting mitosis by interfering with microtubule polymerization. It belongs to antimitotic compounds, which arrest the cell cycle via disrupting microtubule dynamics. Alkalmazása gyermekeknél. Protect from light. vrećice za infuziju) ili u intravensku infuziju obične fiziološke otopine ili otopine glukoze tijekom njezine primjene, što god je prikladnije za bolesnika (vidjeti dio 6. Pozoloji ve uygulama şekli). Call your doctor for medical advice about side effects. (Bkz. Preporučuje se primijeniti otopinu tijekom 5 do 10 A kezelés időtartama általában 4-6 hét. Vincristine merupakan obat yang diproduksi oleh Kalbe Farma. Obat ini mengandung Vincristine sulphate yang digunakan sebagai obat kemoterapi untuk mengobati kanker darah (Leukemia limfoblastik akut; Leukemia mieloid akut), tumor otak, Neuroblastoma (kanker neuroblast atau sel-sel saraf yang belum matang pada anak-anak), kanker paru-paru, kanker kelenjar getah bening (Limfoma Vincristine hanya tersedia dan hanya diberikan secara intravena. Efek samping dan interaksi obat vincristine berpotensi menyebabkan gangguan sistem organ kardiovaskular, sistem saraf pusat, gastrointestinal, dan hepatorenal. fingolimod. Dosis akan ditentukan sesuai luas permukaan tubuh (LPT) pasien. Vinkristin pripada grupi lijekova pod imenom citostatici (lijekovi za liječenje raka). Dosis maksimal sebesar 18,5 mg/m2 setiap minggu. Deskripsi: Vinkristin menghentikan pembelahan sel pada tahap metafase dengan menghambat pembentukan mikrotubulus di spindel mitosis. Vincristine belongs to the category of vinca alkaloids, a class of drugs that function by impeding the proper division of cancer cells. - Dewasa : 0,4-1,4 mg/m 2. Since the growth of normal body cells may also be affected by vincristine, other effects will also occur. Erwachsene (einschließlich älterer Patienten) Die übliche Dosis bei Erwachsenen ist 1,4 mg/m2 (Höchstdosis 2 mg/m2) einmal wöchentlich. How vincristine is given. Vincristine can be given in combination with other cancer drugs.2). seizures. This is not a complete list of side effects and others may occur. Vincristine is a vinca alkaloid naturally occurring in Catharanthus roseus. Felnőtteknek. This page from Great Ormond Street Hospital (GOSH) explains what vincristine is, how it is given and some of the possible side. Penentuan dosis tergantung jenis penyakit, kondisi respons tubuh, dan riwayat terapi/pengobatan lainnya pada saat itu. diarrhea. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. Primjena lijekova za liječenje raka zove se hemoterapija. Korišćenje mera kontracepcije se preporučuje tokom terapije citotoksičnim lekovima. Comments: This dose is the manufacturer recommendation. Distribusi: Tidak melewati sawar darah otak dalam jumlah yang banyak. Bölüm 4. vrećice za infuziju) ili u intravensku infuziju obične fiziološke otopine ili otopine glukoze tijekom njezine primjene, što god je prikladnije za bolesnika (vidjeti dio 6. Vzorec: C.

Metabolisme: Dimetabolisme di hati. Vincristine is freely soluble in water.5 mg/ml when refrigerated and protected from light. Farmakodinamik. Pozoloji ve uygulama şekli). Hos et lite antall pasienter ble livstruende paralyse og påfølgende død forhindret, men medførte nevrologiske skader med begrenset restitusjon. Indications and Usage.A rózsás meténg (Cataranthus roseus, Vincaceae család) alkaloidja. Dosis pemberian vincristine tergantung dari protokol terapi yang dianut. Vincristine may cause hair loss in some patients. Feb 10, 2020 · Pengertian. Wilms tumor. This property makes vincristine a useful compound in anticancer therapies, however, due to its unspecific biological action, vincristine causes severe Vincristine Sulfate Injection, USP, preservative free solution. Vincristine | C46H56N4O10 | CID 5978 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety Aug 31, 2021 · Simple Summary. Nausea, vomiting, weight loss, diarrhea, mouth sores, dizziness, or headache may occur. Linkos. Dersom vinkristin gis intratekalt ved en feiltakelse, er umiddelbar nevrokirurgisk intervensjon nødvendig for å hindre tiltagende paralyse og påfølgende død. Less common. skin rash. Občasno se uporablja tudi kot zaviralec imunske odzivnosti ( imunosupresiv ), na primer pri zdravljenju trombotične trombocitopenične purpure ali kronične Vincristine | C46H56N4O10 | CID 5978 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety Vinkristin (C 46 H 56 N 4 O 10), även sålt under namnet oncovin [1] är ett ofta använt cytostatikum, [2] speciellt bland barn som diagnostiseras med lymfom, leukemi och liknande. The treatment is limited by progressive vincristine-induced neuropathy, possibly including both peripheral sensory and motor nerves, autonomic nervous functions, and the central nervous system. Vincristine sulfate is also being studied in the treatment of Dosis: - Anak : 1,5 - 2,0 mg/m 2. Vincristine sulfate is sometimes used to treat adults and children with other types of cancer, including: Hodgkin lymphoma. ListenVincristine adalah obat kemoterapi yang termasuk dalam kelompok obat yang disebut alkaloid vinca. If you have questions, talk with the doctor. Dávka sa nemá zvyšovať nad hladinu, ktorá má terapeutický prínos (predávkovanie môže mať závažné až smrteľné dôsledky). Farmakokinetik: Absorpsi: Diserap dengan buruk dari saluran GI. Pengawasan melalui pemeriksaan darah lengkap, elektrolit, asam urat, dan Vinkristin je organsko jedinjenje, koje sadrži 46 atoma ugljenika i ima molekulsku masu od 824,958 Da. Dalam mengatasi kanker, obat ini bekerja dengan menghambat atau menghentikan pertumbuhan dan pembelahan sel kanker di dalam tubuh. Vincristine may cause other side effects. Initial dose: 0. Osobine Osobina A vinkrisztin növényi eredetű alkaloid. Osobine. Type. Sitä saadaan eristetyksi kasveista: pikkutalviosta ( Vinca minor) ja ruusukatarasta ( Catharanthus roseus ), joka tunnettiin aikaisemmin nimellä punatalvio ( Vinca rosea ). Other effects, such as hair loss, may not be serious but may cause concern. It belongs to antimitotic compounds, which arrest the cell cycle via disrupting microtubule dynamics. However, there currently exists a lack of published clinical pharmacology data relating to its use in neonate and vincristine. Dojenje. Non-Hodgkin lymphoma (NHL). What is this medication? VINCRISTINE (vin KRIS teen) treats some types of cancer. Vincristine Sulfate Injection, USP is the salt of an alkaloid obtained from a common flowering herb, the periwinkle plant (Vinca rosea Linn). Vincristine may cause hair loss in some patients. Tell your child’s nurse if your child has any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going Vinkristin sülfat bir vesikan olup, bölgesel reaksiyonlara veya ekstravazasyona sebep olabilir. Jul 4, 2022 · Namun, vinkristin juga bisa digunakan sebagai pengobatan tumor Wilms, neuroblastoma, dan rhabdomyosarcoma. hoarseness or loss of ability to speak loudly. Doporučované týdenní dávky vinkristinu podávané po dobu 3 až 4 týdnů vedly u některých pacientů k trvalé remisi. Vincristine Sulfate Injection, USP is the salt of an alkaloid obtained from a common flowering herb, the periwinkle plant (Vinca rosea Linn). A kezelési időszakban összesen 10-12 mg/m 2 összmennyiség Vincristin adható. It works by slowing down the growth of cancer cells. This medication can also Namun, vinkristin juga bisa digunakan sebagai pengobatan tumor Wilms, neuroblastoma, dan rhabdomyosarcoma.

Originally known as leurocristine, it has also been referred to as LCR and VCR. Vincristine interferes with the growth of cancer cells, which are eventually destroyed. Modify Therapy/Monitor Closely. Talk to your doctor about the risks of receiving vincristine injection.Originally known as leurocristine, it has also been referred to as LCR and VCR. A kezelés időtartama általában 4-6 hét. ditingkatkan dengan cara penambahan asam . Vincristine memiliki karakteristik biologis yang khas yaitu mekanisme kerjanya yang sitotoksik, yang disebabkan oleh kemampuan obat ini berikatan dengan tubulin dalam DNA dan menghambat Uporaba. Purpose. NDC 61703–309–06 1 mg, 1 mg/1 mL (single use), flip–top vial (blue cap) NDC 61703–309–16 2 mg, 2 mg/2 mL (single use), flip–top vial (blue cap) This product should be refrigerated between 2°–8°C (36°–46°F). Vincristine may cause other side effects. Pacienti s pravou ITP rezistentní na léčbu splenektomií a na krátkodobou léčbu adrenokortikálními steroidy mohou na vinkristin reagovat, avšak přípravek Vincristine Teva se nedoporučuje jako lék první volby.46H56N4Ó10 Většina lidí Vinkristin je organsko jedinjenje, koje sadrži 46 atoma ugljenika i ima molekulsku masu od 824,958 Da. Nije poznato da li se vinkristin izlučuje u majčino mleko. Anggita Meilana Firdiyanti (E0020060) 2. Vinkristin, také známý jako leurokristin a prodávány pod značkou Oncovin mimo jiné je chemoterapeutický lék používaný k léčbě řady typů rakoviny. Vinkristin se uporablja intravensko pri različnih vrstah raka, zlasti pri ne-Hodgkinovem limfomu, Hodgkinovem limfomu in tudi pri akutni limfoblastni levkemiji, nefroblastomu. Di halaman ini: Indikasi Diffuse large B- cell […] Vincristine umumnya diberikan sekali seminggu, namun untuk lebih jelasnya ikuti instruksi dokter. Farmakodinamik.2. Treba voditi računa da se izbegne ekstravazacija jer to može dovesti do Injekcija razrijeđenog vinkristinsulfata može se infundirati putem fleksibilnog plastičnog spremnika (npr. Vincristine is a vinca alkaloid naturally occurring in Catharanthus roseus. Vincristine is widely used as anticancer therapy for a variety of hematological malignancies.Fezha Obat kemoterapi vinkristin Vinkristin adalah senyawa kimia golongan alkaloid vinca yang berasal dari tanaman Vinca Rosea yang memiliki anti kanker yang diberikan secara intravena dan bekerja menghambat mitosis( menghentikan pembelahan sel ) sehingga menyebabkan sel mati. After treatment with vincristine has ended, or sometimes even during treatment, normal hair growth should return. This is not a complete list of side effects and others may occur. Dosis obat vincristine Feb 13, 2023 · Farmakologi vincristine adalah dengan menghambat suatu fase sel secara spesifik sehingga pembelahan dan pertumbuhan sel tidak dapat berlanjut. This drug may cause tissue damage if the drug leaks from the vein. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. [1,2,4] Pengawasan klinis diperlukan terkait efek samping dan toksisitasnya, terutama gejala neuropati perifer. A chemotherapy nurse will give it to you. Všeobecne individuálne dávky nemajú prekročiť 2 mg a pred podaním každej dávky a po ňom sa majú sledovať počty bielych krviniek Neuromuskular dan skeletal: Kram, sakit rahang, nyeri kaki, myalgia, kehilangan sensasi, kelemahan, neuropati periferal: sering tergantung dosis toksisitas dari vinkristin. Dojenje se ne preporučuje tokom lečenja. Alkalmazása gyermekeknél. Tento lék se podává intravenózně. Farmakokinetik: Absorpsi: Diserap dengan buruk dari saluran GI. [5] This includes acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin's disease, neuroblastoma, and small cell lung cancer among others. Vincristine injeksi yang telah dilarutkan dengan sodium klorida 0,9% dengan konsentrasi 0,0015 mg/mL hingga 0,08 mg/mL bersifat stabil selama 24 jam ketika terhindar dari cahaya dan hanya bertahan 8 jam pada suhu 25°C pada pencahayaan ruangan biasa. 2. Vinblastin akan diberikan lewat suntikan melalui pembuluh darah (intravena/IV) oleh dokter atau petugas medis di bawah pengawasan dokter. Vincristine may increase the risk that you will develop other cancers. fever, sore throat, chills, or other signs of infection. Hati-hati agar tidak terjadi ekstravasasi. Dosis biasa yakni sebanyak 5,5 – 7,4 mg/m2 setiap 7 hari sekali. Pengikatan protein: Ekstensif.1-0. Dalam mengatasi kanker, obat ini bekerja dengan menghambat atau menghentikan pertumbuhan dan pembelahan sel kanker di dalam tubuh.3,4 These drugs act by preventing the polymerization of tubulin to form microtubules, as well as inducing depolymerization of formed tubules. Metabolisme: Dimetabolisme di hati. Vincristine merupakan obat yang diproduksi oleh Kalbe Farma. Vincristin Teva sa zvyčajne používa spolu s inými liekmi na liečbu: • akútnej lymfoblastovej leukémie, čo je rýchlo DESCRIPTION.

A kezelési időszakban összesen 10-12 mg/m 2 összmennyiség Vincristin adható. This property makes vincristine a useful compound in anticancer therapies, however, due to its unspecific biological action, vincristine causes severe Vincristine Sulfate Injection, USP, preservative free solution. Slovenská republika Vincristin Teva. Rhabdomyosarcoma. If you have questions, talk with the doctor. Vinkristin se koristi u kombinaciji sa drugim hemoterapijskim lijekovima primarno za liječenje raka krvi (leukemije i limfomi). Monitor serum potassium during initiation and dosage adjustment of either finererone or weak CYP3A4 inhibitors. Obat ini termasuk ke dalam jenis alkaloid vinca. Tieto lieky zabraňujú rastu rakovinových buniek. 102. Vincristine is a chemotherapy drug that belongs to a group of drugs called vinca alkaloids. Hasil Penelitian Dan Pembahasan Daun Sirsak Tanaman sirsak Sirsak (Annona muricata) merupakan tanaman yang berasal dari Karibia, Amerika Selatan dan Amerika Tengah. Pengertian. What is this medication? VINCRISTINE (vin KRIS teen) treats some types of cancer. If given other ways, this drug can be deadly. fever, sore throat, chills, or other signs of infection. Average mass 824. Discard unused solution. Posle primene leka vena se mora isprati temeljno. Kalau Kamu merasakannyeri, panas, dan bengkak pada sekitar kulit yang disuntik, informasikan dengan dokter. loss of weight. It is stable for at least 6 months at room temperature. Posle primene leka vena se mora isprati temeljno. Adjust finererone dosage as needed. Interaksinya dengan obat-obatan lain dapat berakibat peningkatan konsentrasi vincristine dan risiko efek samping yang ditimbulkan.05 mg/kg IV over one minute once a week. You may report side effects to FDA at 1-800-FDA-1088. Občasno se uporablja tudi kot zaviralec imunske odzivnosti ( imunosupresiv ), na primer pri zdravljenju trombotične trombocitopenične purpure ali kronične Vincristine is a chemotherapy drug that belongs to a group of drugs called vinca alkaloids. Vincristine Sulfate diberikan secara intravena. It is also used to treat other conditions. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Vincristin Teva sa zvyčajne používa spolu s inými liekmi na liečbu: • akútnej lymfoblastovej leukémie, čo je rýchlo VINKRISTIN (L01CA02) Na této stránce jsou podrobné informace o přípravku včetně podrobné informace o indikacích (přesný typ a stádium onemocnění, kombinace s jinými léčivy, linie léčby nežádoucí účinky, apod. Vinkristiinin jälkeen on tullut muitakin vinka-alkaloideja Sebagai alternatif, mulai dengan dosis tunggal, yakni 3,7 mg/m2, ditingkatkan seminggu kemudian secara bertahap sebanyak 1,8 mg/m2 berdasarkan jumlah sel darah. Vincristine is an FDA-approved chemotherapy agent that is used to treat some types of blood cancer as well as some noncancerous conditions. During treatment you usually see a cancer doctor, a chemotherapy nurse or a specialist nurse, and a specialist pharmacist. ChemSpider ID 5758. Simple Summary. Distribusi: Tidak melewati sawar darah otak dalam jumlah yang banyak. Maximum dose: 2 mg/m2 IV over one minute once a week. Dalam memberikan obat ini, diperlukan ketelitian terkait dosis, durasi, dan rute pemberiannya. Some of these may be serious and must be reported to your doctor.5 Vinca alkaloids are cell cycle phase-specific for vinkristin: neurotoxicita (největší z vinca alkaloidů) – parestezie na akrech, porucha svalových reflexů, svalového tonu, motoriky a paralytický ileus, kožní reakce, hypertenze nebo hypotenze, kardiovaskulární poruchy, atrofie očního nervu nebo korová slepota, polyurie, dysurie, porucha sekrece ADH, bronchospazmus, alopecie Popis Vincristin Teva (VšZP_L0153) sol inj 1x1 ml/ 1 mg (mimoriadny dovoz): inkristíniumsulfát patrí do skupiny liekov nazývaných antimitotické cytostatiká. Protinádorový lék ze skupiny rostlinné alkaloidy barvínku (Vinca) a Vinkristin je organsko jedinjenje, koje sadrži 46 atoma ugljenika i ima molekulsku masu od 824,958 Da. Call your doctor for medical advice about side effects. Osobine [uredi | uredi izvor] Osobina Vrednost Broj akceptora Preporučuje se da rastvor vinkristin-sulfata odstoji 5-10 minuta u infuzionoj kesi (50 mL) nakon razblaženja sa 0,9% rastvorom natrijum-hlorida za infuziju (9 mg/mL) ili 5% rastvorom glukoze za infuziju (50 mg/mL). Általában testfelület-négyzetméterenként 1,0-1,4 mg (összesen legfeljebb 2 mg) adható egyszeri adagként, hetente egy alkalommal. Vinkristin sülfatla tedaviyi takiben loköpeninin ortaya çıkması diğer onkolitik maddelerle olduğundan daha az muhtemeldir. Doporučované týdenní dávky vinkristinu podávané po dobu 3 až 4 týdnů vedly u některých pacientů k trvalé remisi. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy). Vinkristin sülfatla tedaviyi takiben loköpeninin ortaya çıkması diğer onkolitik maddelerle olduğundan daha az muhtemeldir.